Melatonin in Mitochondrial Dysfunction and Related Disorders
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چکیده
منابع مشابه
Melatonin in Mitochondrial Dysfunction and Related Disorders
Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased...
متن کاملMitochondrial Dysfunction in Neuropsychiatric Disorders
Mitochondrial disorders were first described in 1962 (Luft, Ikkos, Palmieri, Ernster, & Afzelius, 1962), and were initially thought to be uniformly progressive and fatal with onset in infancy or early childhood, typically associated with severe neurological manifestations, including strokelike episodes, seizures, neuronal degeneration, organ failure and dementia. More recently, clinical observa...
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Most of the living organisms derive their energy requirements from ingested food material through controlled metabolic reactions. Prokaryotes like bacteria obtain the ATP, the energy subunit from series of enzymatic reactions which occur in the cytosol [1]. In contrast to prokaryotes, eukaryotes have evolved a highly specialized double membrane organelles i.e., mitochondria encompassing electro...
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There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis. This evidence includes the direct genetic evidence of pathogenic mutations in mitochondrial proteins in inherited Parkinsonism {such as PA...
متن کاملMitochondrial dysfunction and psychiatric disorders.
Mitochondria are intracellular organelles crucial in the production of cellular energy. Mitochondrial diseases may result from malfunctions in this biochemical cascade. Several investigators have proposed that mitochondrial dysfunction is related to the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD) and schizophrenia (SZ). The authors reviewed recent study findings an...
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ژورنال
عنوان ژورنال: International Journal of Alzheimer's Disease
سال: 2011
ISSN: 2090-0252
DOI: 10.4061/2011/326320